Lovastatin FDA Link Generic

A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.

Also Known As:

Mevacor; 6-Methylcompactin; Lovastatin, (1 alpha(S*))-Isomer; MK-803; Monacolin K; 1 alpha-Isomer Lovastatin; 6 Methylcompactin; Lovastatin, 1 alpha Isomer; MK 803; MK803; alpha-Isomer Lovastatin, 1; Lovastatin, 1 alpha-Isomer; Mevinolin; Butanoic acid, 2-methyl-, 1,2,3,7,8,8a- hexahydro- 3,7- dimethyl- 8- (2- (tetrahydro- 4- hydroxy- 6- oxo- 2H- pyran- 2- yl)ethyl)- 1- naphthalenyl ester, (1S- (1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-

Pharmalogical Action Categories:

Anticholesteremic Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors

Organic Chemicals: 140
- Hydrocarbons: 1726
  - Cyclic Hydrocarbons: 96
    - Aromatic Hydrocarbons: 295
      - Polycyclic Aromatic Hydrocarbons: 2081
        Naphthalenes: 18
        Lovastatin: 1557
Polycyclic Compounds: 7
- Polycyclic Aromatic Hydrocarbons: 2081
  - Naphthalenes: 18
    - Lovastatin: 1557

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F Jara Research Topics

Disease

Drug/Important Bio-Agent (IBA)

Therapy/Procedure